Contrave Reviews (2024 UPDATE): Is It Worth The Risks?

What Is Contrave?

Contrave is a prescription weight loss pill or medicine that aims to help adults who are obese or overweight. The indication on its official website also says that it should be used along with exercise and diet.



It is a prescription-only medicine that’s approved by the FDA to be used as a weight loss medication. This means that you can only take this pill if your doctor recommends it. It’s designed to help you control or suppress your appetite, thus allowing you to lose unwanted weight and keep it off for good.


Who Makes Contrave?

Contrave is a trademark of a biopharmaceutical company called Orexigen Therapeutics, Inc. Its main focus is treating obesity and this medicine is their first one. It was approved and released in September 2014.

It has a European counterpart which is called Mysimba. Their business address is:

3344 N. Torrey Pines Court
Suite 200
La Jolla, CA 92037

Their phone number is (858) 875-8600, with fax number (858) 875-8650. For general concerns, you may send them an email at [email protected] You can also contact Contrave directly at 1-800-905-5576 or 1-877-298-8340.

Best Contrave Alternative

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Who Is Contrave For?

Contrave is for adults with BMI or Body Mass Index of 30 or higher, or for those with 27 BMI or higher but with a weight-related medical condition. It claims to help dieters who are struggling to lose their weight.

There are people who tend to gain weight faster or more rapidly than the others. This can be due to a lot of causes such as:

  • sluggish or under-active thyroid
  • overeating (even healthy foods)
  • dehydration
  • depression
  • staying up too late
  • stressful job
  • relying on your workout alone
  • not eating enough protein
  • certain medications that might stimulate your appetite

If you’ve been gaining weight recently, or already obese and looking for a way to get rid of those unwanted fats, weight loss supplements and diet pills might work for you. However, you have to carefully weigh your alternatives first and don’t just jump into any product that you come across with.

How Does Contrave Work?

Contrave is believed to work on the hunger center and reward system areas of the brain. This means that the medicine helps in reducing hunger while also controlling your food cravings.

The two active medicines of this pill which are naltrexone and bupropion are both well known and usually prescribed individually. Although these two medicines are intended for a totally different medical purpose, there’s a hint that they may help people who are trying to lose weight.

Clinical trials were conducted to see how effective Contrave is as a prescription medicine to aid weight loss. These trials involved several people who are extremely overweight. However, it’s surprising to know that a lot of those people pulled out from the trials due to the side effects that they encountered along the way.

Contrave Ingredients

As previously mentioned, Contrave has two main ingredients which are:

Bupropion Hydrochloride – Bupropion goes by a lot of different names, including Zyban and Wellbutrin. It is usually prescribed as an antidepressant but it may bring a different result or effect when formulated along with other drugs. It is known to help people who want to stop smoking and also to prevent or control the withdrawal’s effects. It also has an appetite reducing property that restores chemical imbalances in the brain, so that one may be prevented from eating excessively.

Naltrexone Hydrochloride – Under the classification of “opiate antagonist,” this drug blocks the activity of opioids. This leads to decreased desire for alcohol and opiates. Naltrexone is marketed and popularly known as Vivitrol and Revia. When used together with Bupropion, this ingredient may affect the brain’s desire for food. In other words, it is considered as an appetite suppressant.

Contrave Side Effects

This is the part where it gets to be quite alarming, as even the official website of Contrave has a lot of warnings and precautions all over their page regarding the use of this medicine. These warnings are very easy to notice, as they are practically everywhere.

To start, Bupropion is highly regarded as a possible cause of suicidal thinking in young adults, adolescents and children. This is why the product is not at all recommended for those who are below 18 years old. Patients who are taking Contrave should also be well-monitored for any suicidal behaviors and thoughts.

You are to stop taking this medicine right away if you are experiencing any of these symptoms:

  • Notions and thoughts of dying and suicide
  • depression
  • anxiety
  • feeling of restlessness or agitation
  • insomnia or trouble sleeping
  • panic attacks
  • violence or anger
  • aggression
  • irritability
  • acting dangerously or impulsively
  • unusual mood or behavioral changes
  • suicide attempts

Other serious side effects that may be experienced while taking Contrave are:

  • hypoglycemia or low blood sugar
  • visual problems (with signs like redness or swelling around the eye are or the eye itself, changes in your vision and eye pain)
  • seizures
  • manic episodes
  • chance of overdose in opioid
  • hepatitis and/or liver damage
  • high blood pressure
  • increased heart rate
  • severe allergic reactions

As for the common side effects that may be brought about by this medicine, the list includes diarrhea, nausea, dry mouth, constipation, insomnia or trouble sleeping, headache, dizziness and vomiting.

Contrave Dosage

For new users, Contrave is advised to be taken beginning with one tablet in the morning for the first week. As you approach to your 4th week, you may gradually increase this dosage to up to two tablets twice a day.

This may still change depending on your doctor’s prescription. The dosage may also differ for patients who are presently taking other medications, and also those with hepatic or renal impairment.

Contrave Reviews

It’s a bit difficult to look for legitimate Contrave reviews as this medicine is only obtained through a medical prescription. This may be the reason why people opt to not go for this product because of its need for a prescription.

We found some reviews of this product and there are those that are okay, with some positive ones and of course the negative ones. There are people who find this medicine helpful as an anti-craving or appetite suppressant.

There are users who would experience side effects such as headaches and constipation, and another one suffered from high blood pressure. Another user said that no difference was noted even after taking the medicine for a while. She said it only brought her severe constipation.

Where To Buy Contrave?

Contrave may only be ordered from its official website, and of course, with a prescription from your doctor. There is also an option to consult with their online doctor so that you may set up a medical profile and have it reviewed for approval.

Once proven or approved that you are a potential candidate for this medicine, you will be notified and will be asked to join a telephone or video consultation with a doctor. Only then will it be decided if this medicine is really what you need.


Does Contrave Really Work Or Is It A Scam?

Even their own website admits it – Contrave is not for everyone. The effect will vary depending on an individual’s reaction to the drug and so this means that you cannot just decide to try this product out just for the heck of it.

With the potential risks and side effects, we think this medicine is not at all the kind of weight loss supplement that you will want to try. It’s better to look for a product that’s not only easier to purchase (without the need for any prescription), but more so, one that does not pose serious and negative health effects that may only harm your body and overall wellness.