Premarin Reviews (2024 UPDATE): Is It Safe And Effective?


What Is Premarin?

Premarin is a brand of FDA approved hormone replacement medication that contains conjugated estrogens.

It is primarily used to treat symptoms of menopause, prevent osteoporosis, some forms of cancer, and other conditions that can cause a decrease in estrogen production.



Who Makes Premarin?

Pfizer is the manufacturer of Premarin. They were once manufactured by Wyeth until Pfizer bought them out in 2009.

Pfizer was founded in 1849 by cousins Charles Pfizer and Charles F. Erhart in New York City.

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Who Is Premarin For?

This hormone replacement is primarily for women who are experiencing a lack of natural estrogen production.

This is specially made for those who are dealing with the symptoms of menopause such as vaginal dryness and hot flashes.

It can also be used by postmenopausal women in preventing osteoporosis.

Furthermore, it can even be used as a treatment for men with prostate cancer, women with breast cancer, and women with ovarian failure who are no longer producing enough estrogen on their own.

While it is important to know who this product is for, it is equally as important to know who should not be taking this medication.

This product can have some very severe life-threatening side effects and interactions if taken by the wrong person.

Here are the people who should not take this medication:

  • Anyone who suffers from bleeding, blood clotting, liver disease, or vaginal bleeding
  • Those who have allergic reactions to estrogens
  • Anyone who has hormone-related cancers
  • Anyone with a history of heart attacks, strokes, or blood clots
  • Pregnant or breastfeeding mothers

If you are concerned about heart disease, stroke, or dementia, you should not use this product as a preventative measure because it can increase the risk of developing these serious conditions.

How Does Premarin Work?

This supplement works to restore the estrogen lost in the body due to conditions such as menopause, ovarian failure, etc.

Estrogen is vital for many important processes that happen in the body.

When your body stops producing enough estrogen naturally, you develop symptoms that negatively affect your quality of life.

These symptoms should go away once the hormone replacement has started working and once your body reaches a normal level of estrogen.

Premarin Ingredients

The oral administration tablets contain conjugated estrogens that were sourced from the urine of pregnant female horses.

The mixture is made up of sodium estrone sulfate, and sodium equaling sulfate.

It also has naturally associated components such as sodium sulfate conjugates, 17αdihydroequilin, 17α estradiol, and 17β-dihydro equilin.

There are also some inactive ingredients such as:

  • Calcium phosphate tribasic
  • Carnauba wax
  • Hydroxypropyl cellulose
  • Hypromellose
  • Lactose monohydrate
  • Magnesium stearate
  • Microcrystalline cellulose
  • Polyethylene glycol
  • Powdered cellulose
  • Sucrose
  • Titanium dioxide

Premarin Side Effects

There are many side effects that come with taking this product, some of them can be severe.

This product has two black-box warnings. The first one is the increased risk of getting endometrial cancer.

The second warning is the increased risk of heart attack, stroke, heart disease, and blood clots.

The side effects can be divided into three categories: “less common but still serious,” “seek medical attention immediately,” and “less serious but common.”

“Serious, but less common” side effects include: heart attack, stroke, blood clots, dementia, breast cancer, cancer of the uterus, cancer of the ovaries, high blood pressure, high blood sugar levels, gallbladder disease, liver problems, benign tumor enlargement, and severe allergic reactions.

“Seek medical attention immediately” side effects include: breast lumps, unusual vaginal bleeding, changes in speech or vision, sudden or severe headaches, severe pains in your chest or legs with or without shortness of breath, weakness, fatigue, swollen lips, tongue, or face.

“Less serious, but common” side effects include: headaches, breast pain, vaginal bleeding or spotting, stomach or abdominal cramps, bloating, nausea, vomiting, hair loss, fluid retention, and yeast infections.

These aren’t even all the possible side effects of this medication. If you would like more information contact your pharmacist or doctor.

Premarin Dosage

The dosage of this supplement varies depending on your condition.

Oral tablets come in doses of  0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, and 1.25 mg.

You should only take this medication exactly as your doctor has prescribed it to you, never more or less or for longer periods than recommended.

If you miss a dose, you should take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dosage.

The medication should only be taken by mouth with food or water as directed by your doctor.

You should never crush, chew, or dissolve the extended-release tablets.

Tell your doctor if your condition gets worse or does not improve.

Premarin Reviews

The reviews for this product have varied depending on the condition the person is treating.

For example, for certain symptoms of menopause, users have praised it for working short term.

However, many of those using the product to get rid of hot flashes specifically claimed that it worked for only a few short weeks and then their hot flashes got worse.

Many users complained of extreme weight gain, and pain in their bones which went away after quitting the medication.

Painful UTI-like symptoms, painful sex, and some issues with hair loss have also been mentioned in the reviews.

Where To Buy Premarin

Premarin is a prescription medication that can only be given to you with a doctor’s recommendation and only picked up at a pharmacy.


Does Premarin Really Work Or Is It A Scam?

There is no reason for us to believe that Premarin is a scam.

It has shown to be successful in replacing estrogen in the body. However, beyond the replacement of estrogen, it doesn’t appear to be helpful for any other condition.

The product is marketed as being great at treating osteoporosis, but there are no studies to prove this. Also, the reviews regarding success in treating osteoporosis have been negative.

It has been used as a treatment for certain cancers, but some of the major side effects of this product are increased risks of developing the exact same cancers that it has been used to treat.

The risks and side effects that come with taking this product do not seem worth the desired result.

There are many hormone replacement therapies on the market that would be much safer and more effective at replacing estrogen and reducing the effects of menopause.